MAPKAPK5 antikoerper, MK5 antikoerper, PRAK antikoerper, MAPKAP-K5 antikoerper, MK-5 antikoerper, mitogen-activated protein kinase-activated protein kinase 5 antikoerper, MAP kinase-activated protein kinase 5 antikoerper, MAPKAPK5 antikoerper, mapkapk5 antikoerper, Mapkapk5 antikoerper
Hintergrund
PRAK (p38-regulated /activated kinase), also referred to as mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK)-5, is an ubiquitously expressed serine/threonine kinase regulated by p38alpha and p38beta MAP kinases. Activated JNK, p38? or p38? are unable to induce phosphorylation of PRAK in vitro. Phosphorylation of PRAK occurs in vivo in response to p38 activation by stress-related extracellular stimuli including UV light, oxidation and proinflammatory cytokines. Two other substrates for p38, MAPKAPK-2 and MAPKAPK-3/3pK, share approximately 45 % sequence homology with PRAK including the phosphorylation motif recognized by p38, Lys-X-Thr-Pro. Activated PRAK has been shown to specifically phosphorylate HSP 27 in vitro, suggesting that the protein may play a role in stress-induced small heat shock protein phosphorylation in vivo.