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IGF1R Antikörper (truncated)
IGF1R
Reaktivität: Human
WB, ELISA, IHC
Wirt: Maus
Monoclonal
3C8B1
unconjugated
Produktnummer ABIN2464067
Produktdetails anti-IGF1R Antikörper
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Target
Alle IGF1R Antikörper anzeigen
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Bindungsspezifität
Alle Epitope für IGF1R Antikörper
truncated
Reaktivität
Alle Reaktivitäten für IGF1R Antikörper
Human
Wirt
Alle Wirte für IGF1R Antikörper
Maus
Klonalität
Alle Klonalitäten für IGF1R Antikörper
Monoklonal
Konjugat
Alle Konjugate für IGF1R Antikörper
Dieser IGF1R Antikörper ist unkonjugiert
Applikation
Alle Applikationen für IGF1R Antikörper
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Immunogen
Ni-NTA purified truncated recombinant IGF1R-His expressed in E. Coli strain BL21 (DE3).
Klon
3C8B1
Isotyp
IgG2b
Top Product
Discover our top product IGF1R Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Western Blot:1:500 - 1:2,000 IHC(P):1:500 - 1:2,000 IHC(F):1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Lagerung
-20 °C
Informationen zur Lagerung
IGF1R monoclonal antibody can be stored at -20 °C, stable for one year.
Details zu IGF1R
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Target
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Andere Bezeichnung
IGF1R (IGF1R Produkte )
Synonyme
CMT2N antikoerper, CD221 antikoerper, IGFIR antikoerper, IGFR antikoerper, JTK13 antikoerper, IGFIRC antikoerper, IGFR1 antikoerper, IGF-1R antikoerper, IGF1R antikoerper, DKFZp469I0618 antikoerper, igf-1r antikoerper, xIGF-1R antikoerper, xIGFR antikoerper, xigf1r antikoerper, A330103N21Rik antikoerper, D930020L01 antikoerper, hyft antikoerper, igf-ir antikoerper, IGF-IR antikoerper, IGF-IRb antikoerper, wu:fb03h06 antikoerper, IGF-IRa antikoerper, sb:eu1090 antikoerper, wu:fi20b10 antikoerper, alanyl-tRNA synthetase antikoerper, insulin like growth factor 1 receptor antikoerper, insulin-like growth factor 1 receptor antikoerper, insulin-like growth factor 1 antikoerper, insulin-like growth factor I receptor antikoerper, insulin like growth factor 1 receptor S homeolog antikoerper, insulin-like growth factor 1b receptor antikoerper, insulin-like growth factor 1a receptor antikoerper, AARS antikoerper, IGF1R antikoerper, Igf1r antikoerper, igf1r antikoerper, Igf1 antikoerper, LOC780503 antikoerper, LOC100136427 antikoerper, igf1r.S antikoerper, igf1rb antikoerper, igf1ra antikoerper
Hintergrund
IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
Gen-ID
3480
UniProt
P08069
Pathways
RTK Signalweg , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Autophagie
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