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SUMO1 Antikörper (full length) (FITC)

Der Ratte Monoklonal Anti-SUMO1-Antikörper wurde für WB, IF und IHC (p) validiert. Er ist geeignet, SUMO1 in Proben von Human zu detektieren. Es sind 4+ Publikationen verfügbar.
Produktnummer ABIN2452136

Kurzübersicht für SUMO1 Antikörper (full length) (FITC) (ABIN2452136)

Target

Alle SUMO1 Antikörper anzeigen
SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Reaktivität

  • 101
  • 81
  • 74
  • 7
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 106
  • 35
  • 2
  • 1
  • 1
Ratte

Klonalität

  • 96
  • 50
Monoklonal

Konjugat

  • 78
  • 10
  • 6
  • 6
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SUMO1 Antikörper ist konjugiert mit FITC

Applikation

  • 117
  • 52
  • 50
  • 47
  • 36
  • 27
  • 26
  • 22
  • 20
  • 15
  • 8
  • 7
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

4D12
  • Bindungsspezifität

    • 15
    • 15
    • 11
    • 9
    • 8
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length

    Spezifität

    Specific to human, simian, mouse and rat SUMO1.

    Kreuzreaktivität (Details)

    Not tested for other species

    Aufreinigung

    The antibody was produced in serum-free medium and purified by proprietary chromatography procedures under mild conditions and conjugated with FITC.

    Sterilität

    Sterile filtered

    Immunogen

    Recombinant GST-fused human SUMO-1 (full length)

    Isotyp

    IgG2a kappa
  • Applikationshinweise

    1. Immunofluorescence staining: 1/100 dilution
    2. Immunohistochemistry,frozen section: 1/100 dilution

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    PBS (x1), 50 % glycerol. Azide and carrier free.

    Konservierungsmittel

    Azide free

    Lagerung

    -20 °C
  • Ulrich: "The fast-growing business of SUMO chains." in: Molecular cell, Vol. 32, Issue 3, pp. 301-5, (2008) (PubMed).

    Saitoh, Uchimura, Tachibana, Sugahara, Saitoh, Nakao: "In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies." in: Experimental cell research, Vol. 312, Issue 8, pp. 1418-30, (2006) (PubMed).

    Cheng, Bawa, Lee, Gong, Yeh: "Role of desumoylation in the development of prostate cancer." in: Neoplasia (New York, N.Y.), Vol. 8, Issue 8, pp. 667-76, (2006) (PubMed).

    Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

  • Target

    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

    Andere Bezeichnung

    SUMO1

    Hintergrund

    SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 /3 show a high degree of similarity to each other and are distinct from SUMO-1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO-1 is conjugated to RanGAP, PML, p53 and IkappaB-alpha to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability. SUMO1 is encoded as a 101 aa protein and first Met and C-terminal 4 aa are removed from the preprotein.

    UniProt

    P63165

    Pathways

    M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway
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