Insulin Receptor Antikörper (Exon 7)

Produktnummer ABIN228599

Der Maus Monoklonal Anti-Insulin Receptor-Antikörper wurde für ELISA, IP und Func validiert. Er ist geeignet, Insulin Receptor in Proben von Human zu detektieren.

Kurzübersicht für Insulin Receptor Antikörper (Exon 7) (ABIN228599)

Target: Insulin Receptor (INSR)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Insulin Receptor Antikörper ist unkonjugiert

Applikation: ELISA, Immunoprecipitation (IP), Functional Studies (Func)

Klon: 83-14

Produktdetails anti-Insulin Receptor Antikörper

Bindungsspezifität: AA 469-592, Exon 7

Spezifität: Recognizes human Insulin receptor, alpha subunit. Inhibits insulin binding (~80 % ) and mimics insulin action. Weakly reacts with bovine, porcine and sheep. Does not react with rabbit, mouse and rat.

Aufreinigung: Protein A purified

Immunogen: IM-9 lymphocytes followed by purified insulin receptor. MW of Antigen: 135kD. Epitope: aa469-592 (exon 7/8). Cellular Localization: Cell membrane.

Type of Immunogen: Cells

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, Func, IP

Usage: Suitable for use in ELISA, Immunoprecipitation, Tyrosine Kinase Assay and Inhibition of insulin binding. May also be used as insulin-like agonist. ELISA: Both as capture and detection. Immunoprecipitation (Use Protein G): 2 μg/mg protein lysate. Tyrosine Kinase Assay: Antibody-mediated capture on microtiter plates. Positive control: IM-9 lymphocyte cells and Placenta. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 10 mM PBS,  pH 7.4. Glycerol free.

Konservierungsmittel: Azide free

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Details zu Insulin Receptor

Target: Insulin Receptor (INSR)

Andere Bezeichnung: INSR / Insulin Receptor

Hintergrund: Name/Gene ID: INSR
Subfamily: Insulin receptor
Family: Protein Kinase

Synonyms: INSR, CD220, ILP receptor, Insulin receptor, IR, HHF5, CD220 antigen

Gen-ID: 3643

UniProt: P06213

Pathways: NF-kappaB Signalweg, RTK Signalweg, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity