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IL1RN Antikörper (Interleukin 1 Receptor Antagonist) Primary Antibody

IL1RN Reaktivität: Human IA, IHC (fro), WB Wirt: Maus Monoclonal 2D11 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2191920
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle IL1RN Antikörper anzeigen
    IL1RN
    Reaktivität
    • 91
    • 37
    • 19
    • 9
    • 9
    • 8
    • 7
    • 4
    • 4
    • 3
    Human
    Wirt
    • 102
    • 41
    • 5
    • 3
    • 3
    • 1
    Maus
    Klonalität
    • 113
    • 42
    Monoklonal
    Konjugat
    • 82
    • 29
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL1RN Antikörper ist unkonjugiert
    Applikation
    • 113
    • 56
    • 47
    • 25
    • 24
    • 20
    • 18
    • 17
    • 13
    • 13
    • 9
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    2D11
  • Applikationshinweise
    For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Muzio, Polentarutti, Facchetti, Peri, Doni, Sironi, Transidico, Salmona, Introna, Mantovani: "Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra." in: European journal of immunology, Vol. 29, Issue 3, pp. 781-8, (1999) (PubMed).

    Muzio, Polentarutti, Sironi, Poli, De Gioia, Introna, Mantovani, Colotta: "Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist." in: The Journal of experimental medicine, Vol. 182, Issue 2, pp. 623-8, (1995) (PubMed).

  • Target
    IL1RN
    Andere Bezeichnung
    Il-1ra3 (IL1RN Produkte)
    Synonyme
    DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, IRAP1, IL1RN, IL-1RA, F630041P17Rik, interleukin 1 receptor antagonist, interleukin 1 receptor antagonist-like, IL1RN, Il1rn, IL1RNL
    Hintergrund
    The antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro- inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.
    Pathways
    NF-kappaB Signalweg, Hormone Transport, Cancer Immune Checkpoints
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