CD46 Antikörper

Produktnummer ABIN2191857

Dieses Anti-CD46-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von CD46 in WB, FACS, IF, IHC (fro) und IA. Geeignet für Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für CD46 Antikörper (ABIN2191857)

Target: CD46

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Klon: MM10

Produktdetails anti-CD46 Antikörper

Kreuzreaktivität (Details): Cross reactivity: Rat CD46 : Yes

Sterilität: 0.2 μm filtered

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: For immune histology, flow cytometry and western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilution. The typical starting working dilution is 1:50. IA: Rat CD46 or mouse CD46 variant as coating on a micro titer plate Positive control

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-CD46 Antikörper (ABIN2191857)

Frolikova, Otcenaskova, Valasková, Postlerova, Stopkova, Stopka, Komrskova: "The Role of Taste Receptor mTAS1R3 in Chemical Communication of Gametes." in: International journal of molecular sciences, Vol. 21, Issue 7, (2020) (PubMed).

Details zu CD46

Target: CD46

Andere Bezeichnung: Membrane Cofactor Protein

Hintergrund: The monoclonal antibody MM10 recognizes membrane cofactor protein (MCP), also known as CD46. MCP is a type I membrane glycoprotein that consists of four isoforms i.e. two C-isoforms (51-58 kDa) and two BC isoforms (59-68 kDa) which arise by alternative splicing of a single CD46 gene. Membrane cofactor protein is expressed on every cell and tissue, with the exception of erythrocytes. Membrane cofactor protein serves to down-regulate the activation of complement on host tissue. MCP is a cofactor for factor 1-mediated cleavage of C3b and C4b and this way serves to protect the host cell against autologous attack. MCP is a receptor for several pathogens including measles virus, group A Streptococcus pyogenes and pathogenic Neisseria. Aliases MCP, CD46, Trophoblast leukocyte common antigen, TLX, measles virus receptor Immunogen Mouse CD46-human Fc fusion protein

Pathways: Regulation of Actin Filament Polymerization