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TLR2 Antikörper (Toll-Like Receptor 2) Primary Antibody

TLR2 Reaktivität: Maus Func, IA, IHC (fro), FACS, IP Wirt: Maus Monoclonal T2-5 unconjugated
Pubmed (5 Referenzen)
Produktnummer ABIN2191804
$729.45
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle TLR2 Antikörper anzeigen
    TLR2
    Reaktivität
    • 7
    • 7
    Maus
    Wirt
    • 6
    • 5
    • 1
    Maus
    Klonalität
    • 6
    • 6
    Monoklonal
    Konjugat
    • 8
    • 2
    • 1
    • 1
    Dieser TLR2 Antikörper ist unkonjugiert
    Applikation
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Functional Studies (Func), Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
    Kreuzreaktivität (Details)
    Cross reactivity: Human TLR2 : Yes
    Sterilität
    0.2 μm filtered
    Klon
    T2-5
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Brüll, Mensink, van den Hurk, Duijvestijn, Plat: "TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols." in: The Journal of biological chemistry, Vol. 285, Issue 5, pp. 2951-8, (2010) (PubMed).

    Spiller, Elson, Ferstl, Dreher, Mueller, Freudenberg, Daubeuf, Wagner, Kirschning: "TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice." in: The Journal of experimental medicine, Vol. 205, Issue 8, pp. 1747-54, (2008) (PubMed).

    Sutmuller, den Brok, Kramer, Bennink, Toonen, Kullberg, Joosten, Akira, Netea, Adema: "Toll-like receptor 2 controls expansion and function of regulatory T cells." in: The Journal of clinical investigation, Vol. 116, Issue 2, pp. 485-94, (2006) (PubMed).

    Roura-Mir, Wang, Cheng, Matsunaga, Dascher, Peng, Fenton, Kirschning, Moody: "Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 3, pp. 1758-66, (2005) (PubMed).

    Leemans, Stokman, Claessen, Rouschop, Teske, Kirschning, Akira, van der Poll, Weening, Florquin: "Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney." in: The Journal of clinical investigation, Vol. 115, Issue 10, pp. 2894-903, (2005) (PubMed).

  • Target
    TLR2
    Andere Bezeichnung
    Toll-Like Receptor 2 (TLR2 Produkte)
    Synonyme
    CD282, TIL4, Ly105, toll like receptor 2, toll-like receptor 2, TLR2, Tlr2, tlr2
    Hintergrund
    The monoclonal antibody T2.5 recognizes mouse Toll-like receptor 2 (TLR2). Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. At present, ligands for several of the TLR's, such as TLR2-6,9, have been identified, confirming their role in first line defense against invading microorganism. In mammals, TLRs are identified as type I transmembrane signaling receptors with an extracellular portion containing leucine-rich repeats with pattern recognition capabilities. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing proliferation of proinflammatory cytokines and upregulation of costimulatory molecules and eventually toinitiation of adaptive immunity. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram- positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. It is suggested that TLR2 is able to recognize such a wide variety of PAMPs (pathogen-specific molecular patterns) by forming heterodimers with other TLRs like e.g. TLR6.. TLR2 is essential for recognizing lipopeptides and lipoproteins from several microorganisms and also peptidoglycans derived from gram-positive bacteria. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2. Aliases TLR2, CD282, TIL4 Immunogen Mouse TLR2 peptide
    Pathways
    TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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