RAD17 Antikörper (PE)

Produktnummer ABIN2178768

Dieser Anti-RAD17 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von RAD17 in FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für RAD17 Antikörper (PE) (ABIN2178768)

Target: RAD17

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD17 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-RAD17 Antikörper (PE)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Rad17

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Kommentare:

Exitation/Emission: 480,565nm/578nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4 °C for 12 months.

Details zu RAD17

Target: RAD17

Andere Bezeichnung: Rad17

Hintergrund: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
Synonyms: RFC, CCYC, Cell cycle checkpoint protein, Cell cycle checkpoint protein RAD17, HRAD 17, hRad17, R24L, Rad 17, Rad 24, RAD1 S. pombe homolog, RAD17, RAD17 homolog, Rad17 like protein, RAD17_HUMAN, RAD17Sp, Rad24, RF C activator 1 homolog, RF C/activator 1 homolog, RF-C/activator 1 homolog.

Gen-ID: 5884