C3 Antikörper

Produktnummer ABIN215710

Dieses Maus Monoklonal-Antikörper erkennt spezifisch C3 in WB, IHC und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Meerschweinchen und Kaninchen.

Kurzübersicht für C3 Antikörper (ABIN215710)

Target: C3 (Complement Component 3 (C3))

Reaktivität: Human, Meerschweinchen, Kaninchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: H13

Produktdetails anti-C3 Antikörper

Spezifität: Recognizes a C3a-determinant (C3 alpha-chain) which is present also on native C3. Allows discrimination of ubiquitous or nonspecifically bound native C3 from biologically active C3b fragment, C3b or C are negative with this clone. The antibody inhibits the anaphylactic function of C3a: the capacity of C3a to induce serotonin release from thrombocytes in vitro is inhibited, similarly, treatment of C3a with the antibody inhibits the C3a-induced skin reaction in vivo. Species cross-reactivity: Guinea pig and rabbit C3/C3a.

Aufreinigung: Protein A purified

Immunogen: Human complement component C3.

Type of Immunogen: Purified protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Approved: IHC, IHC-Fr, WB

Usage: Suitable for use in Immunohistochemistry (frozen sections) and Western blotting. The antibody is, in combination with antibodies to the C3b fragment, an excellent control for distinguishing ubiquitous or nonspecifically bound native C3 from the biologically active C3 fragment. Nonactivated C3 still bears the C3a determinant, whereas activated C3 (C3b, C3d) is C3a-negative. It is therefore useful for immunopathological assays (demonstration of C3 deposition in biopsies) and for C3a assays research purposes.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 1 mL sterile ddH20

Konzentration: Lot specific

Buffer: Lyophilized from PBS,  pH 7.4, 0.5 % BSA, 0.9 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Lyophilized and resuspended forms: store at -20°C.

Details zu C3

Target: C3 (Complement Component 3 (C3))

Andere Bezeichnung: Complement C3

Hintergrund: Name/Gene ID: C3

Synonyms: C3, AHUS5, ARMD9, Complement component C3, CPAMD1, Complement C3, ASP, Complement component 3

Gen-ID: 718

UniProt: P01024

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling