CTLA4 Antikörper

Produktnummer ABIN1981873

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CTLA4 in FACS, IP, ICC und IHC (fro). Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CTLA4 Antikörper (ABIN1981873)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: BNI3

Produktdetails anti-CTLA4 Antikörper

Verwendungszweck: Anti-Hu CD152 Purified

Spezifität: The mouse monoclonal antibody BNI3 recognizes an extracellular domain of human CD152 / CTLA4, an approximately 45 kDa type I transmembrane protein serving as a negative regulator of T cell responses.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Human CD152-IgG heavy chain fusion protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 2-5 μg/mL, Intracellular staining.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze. Do not use after expiration date stamped on vial label.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-CTLA4 Antikörper (ABIN1981873)

Kraszula, Eusebio, Kupczyk, Kuna, Pietruczuk: "[The use of multi-color flow cytometry for identification of functional markers of nTregs in patients with severe asthma]." in: Pneumonologia i alergologia polska, Vol. 80, Issue 5, pp. 389-401, (2012) (PubMed).

Steiner, Moosig, Csernok, Selleng, Gross, Fleischer, Bröker: "Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis." in: Clinical and experimental immunology, Vol. 126, Issue 1, pp. 143-50, (2001) (PubMed).

Steiner, Waase, Rau, Dietrich, Fleischer, Bröker: "Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection." in: Clinical and experimental immunology, Vol. 115, Issue 3, pp. 451-7, (1999) (PubMed).

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: CD152

Hintergrund: Cytotoxic T-lymphocyte associated protein 4,CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.,CTLA4, GSE, GRD4

Gen-ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints