Metabotropic Glutamate Receptor 6 Antikörper

Produktnummer ABIN1944817

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Metabotropic Glutamate Receptor 6 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für Metabotropic Glutamate Receptor 6 Antikörper (ABIN1944817)

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Metabotropic Glutamate Receptor 6 Antikörper

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-Metabotropic Glutamate Receptor 6 Antikörper (ABIN1944817)

Devi, Markandeya, Maddodi, Dhingra, Vardi, Balijepalli, Setaluri: "Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes." in: Pigment cell & melanoma research, Vol. 26, Issue 3, pp. 348-56, (2013) (PubMed).

Dryja, McGee, Berson, Fishman, Sandberg, Alexander, Derlacki, Rajagopalan: "Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 13, pp. 4884-9, (2005) (PubMed).

Hashimoto, Inazawa, Okamoto, Tagawa, Bessho, Honda, Nakanishi: "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6." in: The European journal of neuroscience, Vol. 9, Issue 6, pp. 1226-35, (1997) (PubMed).

Details zu Metabotropic Glutamate Receptor 6

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Andere Bezeichnung: mGluR6

Hintergrund: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

Molekulargewicht: 95468 Da

Gen-ID: 2916

UniProt: O15303