BBS5 Antikörper (AA 108-141)

Produktnummer ABIN1944771

Dieses Anti-BBS5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BBS5 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für BBS5 Antikörper (AA 108-141) (ABIN1944771)

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BBS5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB47475

Produktdetails anti-BBS5 Antikörper

Bindungsspezifität: AA 108-141

Homologie: Pr, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BBS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-BBS5 Antikörper (ABIN1944771)

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

Li, Gerdes, Haycraft, Fan, Teslovich, May-Simera, Li, Blacque, Li, Leitch, Lewis, Green, Parfrey, Leroux, Davidson, Beales, Guay-Woodford, Yoder, Stormo, Katsanis, Dutcher: "Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene." in: Cell, Vol. 117, Issue 4, pp. 541-52, (2004) (PubMed).

Details zu BBS5

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Andere Bezeichnung: BBS5

Hintergrund: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Molekulargewicht: 38755

Gen-ID: 129880

UniProt: Q8N3I7

Pathways: Hedgehog Signalweg