CD22 Antikörper (FITC)
Kurzübersicht für CD22 Antikörper (FITC) (ABIN192422)
Target
Alle CD22 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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    - 
                                            Verwendungszweck
- Anti-Hu CD22 FITC
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                                            Spezifität
- The antibody IS7 reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes, it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.
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                                            Kreuzreaktivität (Details)
- Human
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                                            Aufreinigung
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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                                            Immunogen
- human cell line Reh
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                                            Isotyp
- IgG1
 
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    - 
                                            Applikationshinweise
- Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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    - 
                                            Rekonstitution
- No reconstitution is necessary.
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                                            Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Handhabung
- 
                        Do not freeze. 
 Avoid prolonged exposure to light.
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                                            Lagerung
- 4 °C
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                                            Informationen zur Lagerung
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
 
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    - CD22 (CD22 Molecule (CD22))
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                                            Andere Bezeichnung
- CD22
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                                            Hintergrund
- CD22 Molecule,CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.,SIGLEC2, SIGLEC-2
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                                            Gen-ID
- 933
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                                            UniProt
- P20273
 Target
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