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CD22 Antikörper (FITC)

Der Maus Monoklonal Anti-CD22-Antikörper wurde für FACS validiert. Er ist geeignet, CD22 in Proben von Human zu detektieren.
Produktnummer ABIN192422

Kurzübersicht für CD22 Antikörper (FITC) (ABIN192422)

Target

Alle CD22 Antikörper anzeigen
CD22 (CD22 Molecule (CD22))

Reaktivität

  • 196
  • 61
  • 26
  • 5
  • 3
  • 2
  • 2
  • 1
Human

Wirt

  • 129
  • 81
  • 17
  • 3
Maus

Klonalität

  • 167
  • 61
  • 1
Monoklonal

Konjugat

  • 126
  • 17
  • 13
  • 8
  • 7
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD22 Antikörper ist konjugiert mit FITC

Applikation

  • 142
  • 107
  • 56
  • 51
  • 48
  • 36
  • 29
  • 21
  • 11
  • 11
  • 5
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

IS7
  • Verwendungszweck

    Anti-Hu CD22 FITC

    Spezifität

    The antibody IS7 reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes, it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    human cell line Reh

    Isotyp

    IgG1
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Target

    CD22 (CD22 Molecule (CD22))

    Andere Bezeichnung

    CD22

    Hintergrund

    CD22 Molecule,CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.,SIGLEC2, SIGLEC-2

    Gen-ID

    933

    UniProt

    P20273
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