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MME Antikörper (APC)

Name: MME Antikörper (APC)
Brand: antibodies-online
SKU: ABIN192081
Price: 418.97 EUR
Availability: InStock

MME Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-78 APC

Separation of human neutrophil granulocytes (red-filled) from 10 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD10 (MEM-78) APC antibody (10 μL reagent / 100 μL of peripheral whole blood). (MME Antikörper (APC))

FACS

Surface staining of NALM-6 human pre-B cell leukemia cell line with anti-human CD10 (MEM-78) PE. (MME Antikörper (APC))

FACS

Flow cytometry analysis (surface staining) of human peripheral blood with anti-human CD10 (MEM-78) APC. (MME Antikörper (APC))

FACS

3 Abbildungen

(1 reference)

Produktnummer ABIN192081

Datenblatt (PDF)

Target Alle MME Antikörper anzeigen

MME (Membrane Metallo-Endopeptidase (MME))
Reaktivität
188

45

38

3

2

2

2

2

2

1

1

1

1
Human
Wirt
103

90

2
Maus
Passende Sekundärantikörper
Klonalität
111

83

2
Monoklonal
Konjugat
109

17

16

11

6

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser MME Antikörper ist konjugiert mit APC
Applikation
103

78

75

61

38

27

20

18

10

8

5

5

3

2

2

2

1

1

1

1

1

1

1
Flow Cytometry (FACS)

Verwendungszweck

Anti-Hu CD10 APC

Spezifität

The antibody MEM-78 reacts with an extracellular epitope CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.

Kreuzreaktivität (Details)

Human

Aufreinigung

Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen

NALM-6 human pre-B cell line

Klon

MEM-78

Isotyp

IgG1

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Applikationshinweise

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Rekonstitution

No reconstitution is necessary.

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Do not freeze.
Avoid prolonged exposure to light.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Angelisová, Drbal, Horejsí, Cerný: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, (1999) (PubMed).
Target

MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung

CD10 (MME Produkte)

Hintergrund

Membrane metalloendopeptidase,CD10 (neutral endopeptidase –, NEP, common acute lymphocytic leukemia antigen –, CALLA, membrane metallo-endopeptidase –, MME, enkefalinase) is a 100- kDa cell surface zinc metalloprotease, cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.,CALLA, Neprilysin, Neutral endopeptidase, Enkephalinase, Atriopeptidase, MME

Gen-ID

4311

UniProt

P08473

Pathways

RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration