CCR5 Antikörper (AA 6-20)

Produktnummer ABIN1886891

Der Kaninchen Polyklonal Anti-CCR5-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, CCR5 in Proben von Human zu detektieren.

Kurzübersicht für CCR5 Antikörper (AA 6-20) (ABIN1886891)

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CCR5 Antikörper

Bindungsspezifität: AA 6-20

Aufreinigung: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids 6 to 20 of human CCR5.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu CCR5

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Andere Bezeichnung: CCR5

Hintergrund: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells.Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors.Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells.CCR5 is required for the infection by HIV-1, HIV-2, and SIV.The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1.CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells.The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites.CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

Molekulargewicht: 40 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size