IL1RAP Antikörper (AA 525-540)

Produktnummer ABIN1886887

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL1RAP in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für IL1RAP Antikörper (AA 525-540) (ABIN1886887)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL1RAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-IL1RAP Antikörper

Bindungsspezifität: AA 525-540

Kreuzreaktivität (Details): This polyclonal antibody has no cross activity to other members in the IL-1 receptor family.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 525 to 540 of human IL-1RAcP, which is identical to those of mouse and rat origins.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Andere Bezeichnung: IL-1RAcP

Hintergrund: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment.The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kappaB inducing kinae (NIK) and of NF-kappaB, recruits to the IL-1R complex through IL-1RAcP.IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP.Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response.IL-1RAcP is expressed in many tissues.
Synonyms: IL-1RAcP

Molekulargewicht: 66 kDa

Pathways: NF-kappaB Signalweg, Growth Factor Binding