RRM2B Antikörper (AA 2-17)

Produktnummer ABIN1886848

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RRM2B in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für RRM2B Antikörper (AA 2-17) (ABIN1886848)

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRM2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RRM2B Antikörper

Bindungsspezifität: AA 2-17

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids 2 to 17 of human p53R2.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu RRM2B

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Andere Bezeichnung: p53R2

Hintergrund: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death.Several novel molecules involved in p53 signaling, including p53R2 , Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered.p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase.p53R2 is induced by the reagents, ultraviolet and gamma-irradiation that cause DNA damages.The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA.The isoform of the p53 family member p73 also induces p53R2 expression.p53R2 is an important target of p53 for tumor suppression.

Molekulargewicht: 39 kDa

Pathways: p53 Signalweg, Negative Regulation of intrinsic apoptotic Signaling