RRM2B Antikörper (AA 128-157)

Produktnummer ABIN1537814

Produktdetails anti-RRM2B Antikörper

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Bindungsspezifität: AA 128-157

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRM2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Pr, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RRM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human RRM2B.

Klon: RB36901

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: RRM2B Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu RRM2B

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Andere Bezeichnung: RRM2B (RRM2B Produkte)

Synonyme: p53r2 antikoerper, RRM2B antikoerper, MTDPS8A antikoerper, MTDPS8B antikoerper, P53R2 antikoerper, p53R2 antikoerper, ribonucleotide reductase M2 B (TP53 inducible) S homeolog antikoerper, ribonucleotide reductase regulatory TP53 inducible subunit M2B antikoerper, ribonucleotide reductase M2 B (TP53 inducible) antikoerper, rrm2b.S antikoerper, RRM2B antikoerper, rrm2b antikoerper, Rrm2b antikoerper

Hintergrund: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.

Molekulargewicht: 40737

Gen-ID: 50484

NCBI Accession: NP_001165948, NP_001165949, NP_056528

UniProt: Q7LG56

Pathways: p53 Signalweg, Negative Regulation of intrinsic apoptotic Signaling