IL12RB1 Antikörper (AA 57-458)

Produktnummer ABIN1886561

Der Kaninchen Polyklonal anti-IL12RB1 Antikörper wird verwendet zum Nachweis von IL12RB1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für IL12RB1 Antikörper (AA 57-458) (ABIN1886561)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL12RB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IL12RB1 Antikörper

Bindungsspezifität: AA 57-458

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 57 and 458 of Human IL12RB1

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Hintergrund: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex.This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity.The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling.The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections.Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[provided by RefSeq]

Molekulargewicht: 73 kDa

Gen-ID: 3594

NCBI Accession: NM_005535, NP_005526

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation