Sonic Hedgehog Antikörper (AA 151-162)

Produktnummer ABIN1882186

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Sonic Hedgehog in WB. Er zeigt eine Reaktivität gegenüber Zebrafisch (Danio rerio) und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für Sonic Hedgehog Antikörper (AA 151-162) (ABIN1882186)

Target: Sonic Hedgehog (SHH)

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sonic Hedgehog Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB46723

Produktdetails anti-Sonic Hedgehog Antikörper

Bindungsspezifität: AA 151-162

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This shha antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 151-162 amino acids from the Central region of DANRE shha.

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Sonic Hedgehog Antikörper (ABIN1882186)

Müller, Chang, Albert, Fischer, Tora, Strähle: "Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord." in: Development (Cambridge, England), Vol. 126, Issue 10, pp. 2103-16, (1999) (PubMed).

Zardoya, Abouheif, Meyer: "Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species closely related to the zebrafish." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 23, pp. 13036-41, (1996) (PubMed).

Ekker, Ungar, Greenstein, von Kessler, Porter, Moon, Beachy: "Patterning activities of vertebrate hedgehog proteins in the developing eye and brain." in: Current biology : CB, Vol. 5, Issue 8, pp. 944-55, (1995) (PubMed).

Roelink, Augsburger, Heemskerk, Korzh, Norlin, Ruiz i Altaba, Tanabe, Placzek, Edlund, Jessell: "Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord." in: Cell, Vol. 76, Issue 4, pp. 761-75, (1994) (PubMed).

Details zu Sonic Hedgehog

Target: Sonic Hedgehog (SHH)

Andere Bezeichnung: shha

Hintergrund: Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes. Displays floor plate-inducing activity. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).

Molekulargewicht: 46403

UniProt: Q92008

Pathways: Hedgehog Signalweg, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development