PINK1 Antikörper (AA 237-266)

Produktnummer ABIN1882117

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PINK1 in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für PINK1 Antikörper (AA 237-266) (ABIN1882117)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB7383

Produktdetails anti-PINK1 Antikörper

Bindungsspezifität: AA 237-266

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human PINK1 (PARK6).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PINK1 Antikörper (ABIN1882117)

Mannam, Shinn, Srivastava, Neamu, Walker, Bohanon, Merkel, Kang, Dela Cruz, Ahasic, Pisani, Trentalange, West, Shadel, Elias, Lee: "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 7, pp. L604-19, (2014) (PubMed).

Geisler, Holmström, Skujat, Fiesel, Rothfuss, Kahle, Springer: "PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1." in: Nature cell biology, Vol. 12, Issue 2, pp. 119-31, (2010) (PubMed).

Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: "Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease." in: Archives of neurology, Vol. 61, Issue 12, pp. 1898-904, (2004) (PubMed).

Hatano, Li, Sato, Asakawa, Yamamura, Tomiyama, Yoshino, Asahina, Kobayashi, Hassin-Baer, Lu, Ng, Rosales, Shimizu, Toda, Mizuno, Hattori: "Novel PINK1 mutations in early-onset parkinsonism." in: Annals of neurology, Vol. 56, Issue 3, pp. 424-7, (2004) (PubMed).

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1 (PARK6)

Hintergrund: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Molekulargewicht: 62769

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagie