This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human PINK1 (PARK6).
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Mannam, Shinn, Srivastava, Neamu, Walker, Bohanon, Merkel, Kang, Dela Cruz, Ahasic, Pisani, Trentalange, West, Shadel, Elias, Lee: "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 7, pp. L604-19, (2014) (PubMed).
Geisler, Holmström, Skujat, Fiesel, Rothfuss, Kahle, Springer: "PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1." in: Nature cell biology, Vol. 12, Issue 2, pp. 119-31, (2010) (PubMed).
Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: "Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease." in: Archives of neurology, Vol. 61, Issue 12, pp. 1898-904, (2004) (PubMed).
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.