Tuberin Antikörper (pSer1348)
Kurzübersicht für Tuberin Antikörper (pSer1348) (ABIN1881939)
Target
Alle Tuberin (TSC2) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- pSer1348
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Homologie
- Rat
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Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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Immunogen
- This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1348 of mouse TSC2.
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Isotyp
- Ig Fraction
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anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibody
TSC2 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB13393 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1611-1807) antibodyTSC2 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1601-1750) antibodyTSC2 Reaktivität: Human, Maus, Ratte ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibodyTSC2 Reaktivität: Human ELISA, WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pSer1387) antibodyTSC2 Reaktivität: Human DB, IF Wirt: Kaninchen Polyclonal RB11388 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1397-1426) antibodyTSC2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB42388 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 900-1150) antibodyTSC2 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pThr1462) antibodyTSC2 Reaktivität: Human, Maus, Ratte ELISA, WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1396-1496) antibodyTSC2 Reaktivität: Human ELISA, WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pThr927) antibodyTSC2 Reaktivität: Maus, Ratte ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- DB: 1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Haltbarkeit
- 6 months
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- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
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Andere Bezeichnung
- TSC2
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Hintergrund
- In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
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Molekulargewicht
- 202071
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UniProt
- Q61037
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Pathways
- RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
Target
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