Tuberin Antikörper (pThr1373)

Produktnummer ABIN1881935

Der Kaninchen Polyklonal Anti-Tuberin-Antikörper wurde für DB validiert. Er ist geeignet, Tuberin in Proben von Ratte zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für Tuberin Antikörper (pThr1373) (ABIN1881935)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tuberin Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB41276

Produktdetails anti-Tuberin Antikörper

Bindungsspezifität: pThr1373

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Tuberin Antikörper (ABIN1881935)

Larson, Liu, Stevens, Li, Li, Evers, Gao: "Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24987-98, (2010) (PubMed).

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, (2009) (PubMed).

Shiono, Kobayashi, Takahashi, Sun, Abe, Zhang, Wang, Piao, Takagi, Mineki, Taka, Tada, Sonobe, Momose, Ueda, Hino: "The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition." in: Oncogene, Vol. 27, Issue 52, pp. 6690-7, (2008) (PubMed).

Details zu Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Andere Bezeichnung: TSC2

Hintergrund: Acts as a tumor suppressor, may play a role in cell cycle regulation, acute phase response, and negative regulation of cell proliferation [RGD].

Molekulargewicht: 201278

NCBI Accession: NP_036812

UniProt: P49816

Pathways: RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus