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MBD2 Antikörper (AA 250-279)

Dieses Anti-MBD2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MBD2 in WB und IF. Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.
Produktnummer ABIN1881531

Kurzübersicht für MBD2 Antikörper (AA 250-279) (ABIN1881531)

Target

Alle MBD2 Antikörper anzeigen
MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reaktivität

  • 48
  • 24
  • 7
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 45
  • 2
  • 1
Kaninchen

Klonalität

  • 42
  • 6
Polyklonal

Konjugat

  • 31
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MBD2 Antikörper ist unkonjugiert

Applikation

  • 41
  • 18
  • 10
  • 7
  • 5
  • 5
  • 4
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)

Klon

RB41663
  • Bindungsspezifität

    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 250-279

    Homologie

    M

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This MBD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the Central region of human MBD2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    IF: 1:10~50. WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

    Guey, García-Closas, Murta-Nascimento, Lloreta, Palencia, Kogevinas, Rothman, Vellalta, Calle, Marenne, Tardón, Carrato, García-Closas, Serra, Silverman, Chanock, Real, Malats: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, (2010) (PubMed).

    Hosgood, Menashe, He, Chanock, Lan: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, (2009) (PubMed).

  • Target

    MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

    Andere Bezeichnung

    MBD2

    Hintergrund

    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

    Molekulargewicht

    43255

    NCBI Accession

    NP_003918, NP_056647

    UniProt

    Q9UBB5

    Pathways

    Chromatin Binding
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