MBD2 Antikörper (Methyl-CpG Binding Domain Protein 2)

Details for Product anti-MBD2 Antibody No. ABIN6569193
Target
Reaktivität
Human, Maus, Ratte
67
26
9
3
2
2
2
2
2
2
2
2
1
1
Wirt
Kaninchen
61
7
2
Klonalität
Polyklonal
Konjugat
Dieser MBD2 Antikörper ist unkonjugiert
6
5
5
5
5
5
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
62
44
14
3
3
2
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human MBD2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung MBD2 (MBD2 Antibody Abstract)
Hintergrund

Synonyms: Demethylase,DMTase,MBD 2,Mbd2,MBD2,MBD2a,Methyl CpG binding domain protein 2,Methyl CpG binding protein MBD2,Methyl-CpG-binding domain protein 2,Methyl-CpG-binding protein MBD2,NY CO 41

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 53kDa

Calculated_MW: 31kDa/43kDa

Gen-ID 8932
UniProt Q9UBB5
Pathways Chromatin Binding
Applikations-hinweise WB 1:200 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Methyl-CpG Binding Domain Protein 2 (MBD2) antibody (ABIN6569193) Immunohistochemistry of paraffin-embedded mouse kidney using MBD2 antibody.
Image no. 2 for anti-Methyl-CpG Binding Domain Protein 2 (MBD2) antibody (ABIN6569193) Western blot analysis of extracts of various cell lines, using MBD2 antibody.
Image no. 3 for anti-Methyl-CpG Binding Domain Protein 2 (MBD2) antibody (ABIN6569193) Immunohistochemistry of paraffin-embedded rat lung using MBD2 antibody.