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KIT Antikörper (pSer959)

Der Kaninchen Polyklonal Anti-KIT-Antikörper wurde für DB validiert. Er ist geeignet, KIT in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.
Produktnummer ABIN1881482

Kurzübersicht für KIT Antikörper (pSer959) (ABIN1881482)

Target

Alle KIT Antikörper anzeigen
KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reaktivität

  • 653
  • 234
  • 65
  • 29
  • 27
  • 25
  • 16
  • 12
  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 523
  • 167
  • 40
  • 4
  • 2
  • 1
Kaninchen

Klonalität

  • 515
  • 220
  • 2
Polyklonal

Konjugat

  • 255
  • 70
  • 60
  • 59
  • 46
  • 46
  • 11
  • 10
  • 10
  • 10
  • 10
  • 10
  • 10
  • 10
  • 10
  • 10
  • 10
  • 9
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser KIT Antikörper ist unkonjugiert

Applikation

  • 376
  • 330
  • 282
  • 146
  • 91
  • 91
  • 85
  • 52
  • 45
  • 42
  • 42
  • 42
  • 10
  • 8
  • 6
  • 6
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dot Blot (DB)

Klon

RB39152
  • Bindungsspezifität

    • 33
    • 23
    • 23
    • 23
    • 19
    • 19
    • 16
    • 16
    • 16
    • 16
    • 16
    • 16
    • 14
    • 12
    • 11
    • 10
    • 10
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    pSer959

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This KIT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S959 of human KIT.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    DB: 1:500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Molderings, Meis, Kolck, Homann, Frieling: "Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects." in: Immunogenetics, Vol. 62, Issue 11-12, pp. 721-7, (2010) (PubMed).

    Cheng, Zhou, Wu, Boriboun, Thorne, Liu, Xiang, Zeng, Tanaka, Tang, Kishore, Tomasson, Miller, Losordo, Qin: "CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity." in: Circulation research, Vol. 107, Issue 9, pp. 1083-93, (2010) (PubMed).

    Chi, Chen, Zhang, Guo, Wongvipat, Shamu, Fletcher, Dewell, Maki, Zheng, Antonescu, Allis, Sawyers: "ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours." in: Nature, Vol. 467, Issue 7317, pp. 849-53, (2010) (PubMed).

    Rossi, Gasparotto, Toffolatti, Pastrello, Gallina, Marzotto, Sartor, Barbareschi, Cantaloni, Messerini, Bearzi, Arrigoni, Mazzoleni, Fletcher, Casali, Talamini, Maestro, Maestra, Dei Tos: "Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size." in: The American journal of surgical pathology, Vol. 34, Issue 10, pp. 1480-91, (2010) (PubMed).

    Chen, Zong, Zhao, Shi: "Efficacy evaluation of imatinib treatment in patients with gastrointestinal stromal tumors: a meta-analysis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4227-32, (2010) (PubMed).

  • Target

    KIT (Mast/stem Cell Growth Factor Receptor (KIT))

    Andere Bezeichnung

    KIT

    Hintergrund

    This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

    Molekulargewicht

    109865

    NCBI Accession

    NP_000213, NP_001087241

    UniProt

    P10721

    Pathways

    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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