KIT Antikörper (pSer891)

Produktnummer ABIN1881481

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch KIT in DB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für KIT Antikörper (pSer891) (ABIN1881481)

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIT Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB41777

Produktdetails anti-KIT Antikörper

Bindungsspezifität: pSer891

Homologie: B, Pig

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KIT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S891 of human KIT.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-KIT Antikörper (ABIN1881481)

Molderings, Meis, Kolck, Homann, Frieling: "Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects." in: Immunogenetics, Vol. 62, Issue 11-12, pp. 721-7, (2010) (PubMed).

Cheng, Zhou, Wu, Boriboun, Thorne, Liu, Xiang, Zeng, Tanaka, Tang, Kishore, Tomasson, Miller, Losordo, Qin: "CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity." in: Circulation research, Vol. 107, Issue 9, pp. 1083-93, (2010) (PubMed).

Chi, Chen, Zhang, Guo, Wongvipat, Shamu, Fletcher, Dewell, Maki, Zheng, Antonescu, Allis, Sawyers: "ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours." in: Nature, Vol. 467, Issue 7317, pp. 849-53, (2010) (PubMed).

Rossi, Gasparotto, Toffolatti, Pastrello, Gallina, Marzotto, Sartor, Barbareschi, Cantaloni, Messerini, Bearzi, Arrigoni, Mazzoleni, Fletcher, Casali, Talamini, Maestro, Maestra, Dei Tos: "Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size." in: The American journal of surgical pathology, Vol. 34, Issue 10, pp. 1480-91, (2010) (PubMed).

Chen, Zong, Zhao, Shi: "Efficacy evaluation of imatinib treatment in patients with gastrointestinal stromal tumors: a meta-analysis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4227-32, (2010) (PubMed).

Details zu KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Andere Bezeichnung: KIT

Hintergrund: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 109865

NCBI Accession: NP_000213, NP_001087241

UniProt: P10721

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity