ING2 Antikörper (AA 112-141)

Produktnummer ABIN1881460

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ING2 in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für ING2 Antikörper (AA 112-141) (ABIN1881460)

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ING2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40520

Produktdetails anti-ING2 Antikörper

Bindungsspezifität: AA 112-141

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ING2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-141 amino acids from the Central region of human ING2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ING2 Antikörper (ABIN1881460)

Ythier, Larrieu, Binet, Binda, Brambilla, Gazzeri, Pedeux: "Sumoylation of ING2 regulates the transcription mediated by Sin3A." in: Oncogene, Vol. 29, Issue 44, pp. 5946-56, (2010) (PubMed).

Larrieu, Ythier, Binet, Brambilla, Brambilla, Sengupta, Pedeux: "ING2 controls the progression of DNA replication forks to maintain genome stability." in: EMBO reports, Vol. 10, Issue 10, pp. 1168-74, (2009) (PubMed).

Kumamoto, Fujita, Kurotani, Saito, Unoki, Hagiwara, Shiga, Bowman, Yanaihara, Okamura, Nagashima, Miyamoto, Takenoshita, Yokota, Harris: "ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression." in: International journal of cancer. Journal international du cancer, Vol. 125, Issue 6, pp. 1306-15, (2009) (PubMed).

Borkosky, Gunduz, Nagatsuka, Beder, Gunduz, Ali, Rodriguez, Cilek, Tominaga, Yamanaka, Shimizu, Nagai: "Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma." in: Journal of cancer research and clinical oncology, Vol. 135, Issue 5, pp. 703-13, (2009) (PubMed).

Unoki, Kumamoto, Robles, Shen, Zheng, Harris: "A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis." in: FEBS letters, Vol. 582, Issue 28, pp. 3868-74, (2008) (PubMed).

Details zu ING2

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Andere Bezeichnung: ING2

Hintergrund: This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.

Molekulargewicht: 32808

NCBI Accession: NP_001555

UniProt: Q9H160

Pathways: Chromatin Binding, Autophagie, Negative Regulation of intrinsic apoptotic Signaling