Cyclin D2 Antikörper (C-Term)

Produktnummer ABIN1881176

Der Kaninchen Polyklonal Anti-Cyclin D2-Antikörper wurde für WB validiert. Er ist geeignet, Cyclin D2 in Proben von Maus zu detektieren.

Kurzübersicht für Cyclin D2 Antikörper (C-Term) (ABIN1881176)

Target: Cyclin D2 (CCND2)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB43028

Produktdetails anti-Cyclin D2 Antikörper

Bindungsspezifität: AA 258-285, C-Term

Homologie: Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse CCND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the C-terminal region of mouse CCND2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu Cyclin D2

Target: Cyclin D2 (CCND2)

Andere Bezeichnung: CCND2

Hintergrund: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Molekulargewicht: 32897

NCBI Accession: NP_033959

UniProt: P30280

Pathways: Zellzyklus, Mitotic G1-G1/S Phases