Cyclin D1 Antikörper (C-Term)

Produktnummer ABIN1881175

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Cyclin D1 in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 6+ Publikationen erwähnt.

Kurzübersicht für Cyclin D1 Antikörper (C-Term) (ABIN1881175)

Target: Cyclin D1 (CCND1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB42158

Produktdetails anti-Cyclin D1 Antikörper

Bindungsspezifität: AA 267-294, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-294 amino acids from the C-terminal region of human CCND1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Cyclin D1 Antikörper (ABIN1881175)

Yang, Wei, Wang, Shen, Xu, Cao: "TRAF4 enhances oral squamous cell carcinoma cell growth, invasion and migration by Wnt-β-catenin signaling pathway." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 11837-46, (2016) (PubMed).

Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: "Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase." in: Cancer cell, Vol. 18, Issue 4, pp. 329-40, (2010) (PubMed).

Halilovic, She, Ye, Pagliarini, Sellers, Solit, Rosen: "PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling." in: Cancer research, Vol. 70, Issue 17, pp. 6804-14, (2010) (PubMed).

Zheng, Armes, Slavin, Zhu, Ni: "Preliminary comparison of tumor biologic factors in breast carcinomas from Australian and Chinese women." in: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, Vol. 32, Issue 3, pp. 155-60, (2010) (PubMed).

Satiroglu-Tufan, Dodurga, Gok, Cetinkaya, Feitelson: "RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells." in: Genetics and molecular research : GMR, Vol. 9, Issue 3, pp. 1557-67, (2010) (PubMed).

Iwatani, Fujimoto, Ito: "Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction." in: Biochemical and biophysical research communications, Vol. 400, Issue 3, pp. 426-31, (2010) (PubMed).

Details zu Cyclin D1

Target: Cyclin D1 (CCND1)

Andere Bezeichnung: CCND1

Hintergrund: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Molekulargewicht: 33729

NCBI Accession: NP_444284

UniProt: P24385

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling