ATG13 Antikörper (pSer355)

Produktnummer ABIN1881081

Produktdetails anti-ATG13 Antikörper

Target: ATG13 (Autophagy Related 13 (ATG13))

Bindungsspezifität: pSer355

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG13 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATG13 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S355 of human ATG13.

Klon: RB40774

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ATG13 Antikörper (ABIN1881081)

Ferreira, Pan-Hammarström, Graham, Gateva, Fontán, Lee, Ortmann, Urcelay, Fernández-Arquero, Núñez, Jorgensen, Ludviksson, Koskinen, Haimila, Clark, Klareskog, Gregersen, Behrens, Hammarström: "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency." in: Nature genetics, Vol. 42, Issue 9, pp. 777-80, (2010) (PubMed).

Koh, Lin, Jedd, Wong: "Sirius PSB: a generic system for analysis of biological sequences." in: Journal of bioinformatics and computational biology, Vol. 7, Issue 6, pp. 973-90, (2009) (PubMed).

Mercer, Kaliappan, Dennis: "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy." in: Autophagy, Vol. 5, Issue 5, pp. 649-62, (2009) (PubMed).

Ganley, Lam, Wang, Ding, Chen, Jiang: "ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12297-305, (2009) (PubMed).

Chan, Longatti, McKnight, Tooze: "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism." in: Molecular and cellular biology, Vol. 29, Issue 1, pp. 157-71, (2008) (PubMed).

Details zu ATG13

Target: ATG13 (Autophagy Related 13 (ATG13))

Andere Bezeichnung: ATG13 (ATG13 Produkte)

Hintergrund: Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.

Molekulargewicht: 56572

NCBI Accession: NP_001136145, NP_001192048, NP_001192049, NP_001192050, NP_001192051, NP_055556

UniProt: O75143

Pathways: PI3K-Akt Signalweg, Autophagie