ASK1 Antikörper

Produktnummer ABIN187833

Der Kaninchen Polyklonal anti-ASK1 Antikörper (ABIN187833) detektiert spezifisch ASK1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ASK1 Antikörper (ABIN187833)

Target: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ASK1 Antikörper

Spezifität: This antibody detects ASK1. Species Reactivity: Human, other species not tested.

Immunogen: Synthetic peptide corresponding to amino acids 1356 to 1375 of human ASK1 protein.

Anwendungsinformationen

Applikationshinweise: Western blot: Use 0.5-1 µg/ml. Detects a 155 kDa band in SW1353 whole cell lysate. The optimal dilution for a specific application should be determined by the researcher. Note: immunogen sequence differs in mouse by last two amino acids.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Provided at 0.5 mg/ml in PBS solution containing 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu ASK1

Target: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Andere Bezeichnung: MEKK5 / ASK1

Hintergrund: Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death, and a catalytically inactive form of ASK1 inhibit TNF-alpha-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.

Pathways: MAPK Signalweg, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response