Arrestin 3 Antikörper (Arrestin, beta 2) (Internal Region)

Details for Product anti-ARRB2 Antibody No. ABIN185395, Anbieter: Anmelden zum Anzeigen
Antigen
  • ARRB2
  • arb2
  • arr2
  • arrestin
  • barr2
  • betaarr2
  • ARB2
  • ARR2
  • BARR2
  • BARRES
  • AI326910
  • AW122872
  • arrb2
  • zgc:64007
  • arrestin beta 2
  • arrestin, beta 2
  • arrestin beta 2 L homeolog
  • arrestin, beta 2b
  • ARRB2
  • arrb2
  • Arrb2
  • arrb2.L
  • arrb2b
Epitop
Internal Region
12
9
8
5
4
3
3
3
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
89
36
29
10
7
7
7
6
4
4
3
3
2
2
2
1
Wirt
Ziege
55
21
13
Klonalität
Polyklonal
Konjugat
Dieser Arrestin 3 Antikörper ist unkonjugiert
4
2
1
1
1
1
Methodentyp
Peptide ELISA
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
83
42
38
26
23
16
4
3
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Peptide with sequence C-HDHIPLPRPQS, from the internal region of the protein sequence according to NP_004304.1, NP_945355.1.
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN369151.
Spezifität This antibody is expected to recognise both reported isoforms NP_004304.1 and NP_945355.1.
Kreuzreaktivität (Details) No crossreactivity is expected with Arrestin beta 1.
Reinigung Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Andere Bezeichnung Arrestin beta 2 (ARRB2 Antibody Abstract)
Hintergrund Synonyms: arrestin, beta 2, ARRB2, HGNC:712, ARB2, ARR2, DKFZp686L0365, arrestin beta 2, beta-arrestin 2, BARR2
Molekulargewicht 46.1kDa
Gen-ID 409
NCBI Accession NP_004304, NP_945355
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Phototransduction, Thromboxane A2 Receptor Signaling
Applikationshinweise ELISA: antibody detection limit dilution 1:32000.
Western blot: Approx 40 kDa band observed in Human Brain lysates (calculated MW of 46.1 kDa according to NP_004304.1 and 44.4 according to NP_945355.1). Recommended concentration: 0.3-1 µg/mL. An anonymous customer found positive results in WB on Rat aortic smooth muscle. An anonymous customer found positive results in WB on Mouse smooth muscle. An anonymous customer found positive results in WB on Mouse aortic smooth muscle. An anonymous customer found positive results in WB on Human colon adenocarcinoma cells (SW480).
IHC: In paraffin embedded Human Cerebellum shows mainly nuclear staining of purkinje cells and neuronal cells in the Molecular Layer. Recommended concentration: 4-6 µg/mL. Immunoprecipitation: This antibody has been successfully used in IP from rat leukocytes as described in the following paper: Zakrzewicz et al, Immunobiology. 2011 Jul,216(7):854-61, PMID: 21193245.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 100µg/200µl
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Minimize freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Aliquot and store at -20 °C.
Bilder des Herstellers
 image for anti-Arrestin, beta 2 (ARRB2) (Internal Region) antibody (ABIN185395) ABIN185395 (0.03µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer)....
Produkt verwendet in: Zakrzewicz, Krasteva, Wilhelm, Dietrich, Wilker, Padberg, Wygrecka, Grau: "Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys." in: Immunobiology, Vol. 216, Issue 7, pp. 854-61, 2011 (PubMed).

Napolitano, Pasqualetti, Usiello, Santini, Pacini, Sciamanna, Errico, Tassone, Di Dato, Martella, Cuomo, Fisone, Bernardi, Mandolesi, Mercuri, Standaert, Pisani: "Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia." in: Neurobiology of disease, Vol. 38, Issue 3, pp. 434-45, 2010 (PubMed).

Allgemeine Veröffentlichungen Lefkowitz, Shenoy: "Transduction of receptor signals by beta-arrestins." in: Science (New York, N.Y.), Vol. 308, Issue 5721, pp. 512-7, 2005 (PubMed).

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