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IGF1R Antikörper (Chain alpha)

IGF1R Reaktivität: Human WB, FACS, IHC (p) Wirt: Maus Monoclonal 1H7 unconjugated
Produktnummer ABIN181732
  • Target Alle IGF1R Antikörper anzeigen
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Bindungsspezifität
    • 23
    • 23
    • 19
    • 14
    • 12
    • 12
    • 12
    • 10
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Chain alpha
    Reaktivität
    • 192
    • 111
    • 94
    • 16
    • 8
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 173
    • 32
    • 2
    • 1
    • 1
    Maus
    Klonalität
    • 175
    • 34
    Monoklonal
    Konjugat
    • 128
    • 9
    • 8
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Dieser IGF1R Antikörper ist unkonjugiert
    Applikation
    • 131
    • 72
    • 63
    • 61
    • 32
    • 26
    • 18
    • 13
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody recognises CD221. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221. We recommend the use of BM2226LE for this purpose.
    Aufreinigung
    Affinity Chromatography on Protein G
    Immunogen
    Spleen cells from immunised BALB/c mice were fused with cells of the SP2/0 myeloma cell line.
    Klon
    1H7
    Isotyp
    IgG1
    Top Product
    Discover our top product IGF1R Primärantikörper
  • Applikationshinweise
    Western Blot. Flow Cytometry: Use 10 μL of 1/10 diluted antibody to label 10^6 cells in 100 μL. Immunohistochemistry on Paraffin Sections (1/10-1/40): Requires protein digestionpre-treatment. Recommended Positive Control: Pancreas, placenta.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Beuschlein, Jakoby, Mentz, Zambetti, Jung, Reincke, Süss, Hantel: "IGF1-R inhibition and liposomal doxorubicin: Progress in preclinical evaluation for the treatment of adrenocortical carcinoma." in: Molecular and cellular endocrinology, Vol. 428, pp. 82-8, (2016) (PubMed).

    Hantel, Lewrick, Reincke, Süss, Beuschlein: "Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma." in: The Journal of endocrinology, Vol. 213, Issue 2, pp. 155-61, (2012) (PubMed).

    Hantel, Lewrick, Schneider, Zwermann, Perren, Reincke, Süss, Beuschlein: "Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 2, pp. 943-52, (2010) (PubMed).

  • Target
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Andere Bezeichnung
    CD221 / IGF1R (IGF1R Produkte)
    Hintergrund
    CD221 is a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor
    Gen-ID
    3480
    NCBI Accession
    NP_000866
    UniProt
    P08069
    Pathways
    RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie
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