PINK1 Antikörper (Internal Region)

Produktnummer ABIN1738106

Produktdetails anti-PINK1 Antikörper

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Bindungsspezifität: AA 350-500, Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Reacts with human and mouse PINK1 protein

Aufreinigung: Antigen affinity purified

Immunogen: A genomic peptide made to an internal region of the human PINK1 protein (within residues 350-500).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:500-1:1000, IHC1:100, IHC-P 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.17 mg/mL

Buffer: PBS, Sodium azide 0.05 %

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 6 months

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1 (PINK1 Produkte)

Synonyme: BEST:GH23468 antikoerper, CG4523 antikoerper, Dmel\\CG4523 antikoerper, PINK antikoerper, PINK1 antikoerper, dPINK1 antikoerper, dPink1 antikoerper, pink1 antikoerper, wu:fc39e12 antikoerper, zgc:101729 antikoerper, BRPK antikoerper, PARK6 antikoerper, 1190006F07Rik antikoerper, AU042772 antikoerper, AW557854 antikoerper, mFLJ00387 antikoerper, PTEN-induced putative kinase 1 antikoerper, PTEN induced putative kinase 1 antikoerper, Pink1 antikoerper, PINK1 antikoerper, pink1 antikoerper

Hintergrund: PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2.

Gen-ID: 65018

UniProt: Q9BXM7

Pathways: Autophagie