PINK1 Antikörper (Internal Region)

Produktnummer ABIN1738106

Der Kaninchen Polyklonal Anti-PINK1-Antikörper wurde für IHC, ICC, IF und IHC (p) validiert. Er ist geeignet, PINK1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für PINK1 Antikörper (Internal Region) (ABIN1738106)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PINK1 Antikörper

Bindungsspezifität: AA 350-500, Internal Region

Spezifität: Reacts with human and mouse PINK1 protein

Aufreinigung: Antigen affinity purified

Immunogen: A genomic peptide made to an internal region of the human PINK1 protein (within residues 350-500).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:500-1:1000, IHC1:100, IHC-P 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.17 mg/mL

Buffer: PBS, Sodium azide 0.05 %

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 6 months

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1

Hintergrund: PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2.

Gen-ID: 65018

UniProt: Q9BXM7

Pathways: Autophagie