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BRCA1 Antikörper (AA 229-335)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch BRCA1 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.
Produktnummer ABIN1724848

Kurzübersicht für BRCA1 Antikörper (AA 229-335) (ABIN1724848)

Target

Alle BRCA1 Antikörper anzeigen
BRCA1 (Breast Cancer 1 (BRCA1))

Reaktivität

  • 226
  • 39
  • 28
  • 3
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 176
  • 60
  • 2
Maus

Klonalität

  • 180
  • 58
Monoklonal

Konjugat

  • 96
  • 20
  • 11
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 2
  • 1
Dieser BRCA1 Antikörper ist unkonjugiert

Applikation

  • 125
  • 60
  • 54
  • 44
  • 41
  • 40
  • 30
  • 27
  • 25
  • 20
  • 13
  • 10
  • 9
  • 9
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), ELISA

Klon

6C6D2
  • Bindungsspezifität

    • 44
    • 21
    • 16
    • 15
    • 15
    • 12
    • 12
    • 10
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 229-335

    Verwendungszweck

    BRCA1 Antibody

    Aufreinigung

    Purified antibody

    Immunogen

    Purified recombinant fragment of human BRCA1 (AA: 229-335) expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Muñoz, Laulier, Gunn, Cheng, Robbiani, Nussenzweig, Stark: "RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1." in: The Journal of biological chemistry, Vol. 287, Issue 48, pp. 40618-28, (2012) (PubMed).

  • Target

    BRCA1 (Breast Cancer 1 (BRCA1))

    Andere Bezeichnung

    BRCA1

    Hintergrund

    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.


    Molekulargewicht

    207.7 kDa

    Gen-ID

    672

    UniProt

    P38398

    Pathways

    Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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