CDC25C
Reaktivität: Human
WB, IP
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA: 1/10000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Zheng, Kosti, Loffredo, Bowman, Mechanic, Perlmutter, Jones, Shields, Harris: "Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 9, pp. 2199-210, (2010) (PubMed).
Busch, Barton, Morgenstern, Götz, Günther, Noll, Montenarh: "The G2/M checkpoint phosphatase cdc25C is located within centrosomes." in: The international journal of biochemistry & cell biology, Vol. 39, Issue 9, pp. 1707-13, (2007) (PubMed).
Target
CDC25C
(Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C))
Cdc25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It has been highly conserved during evolution and it plays a key role in the regulation of cell division. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Cdc25C is mainly expressed in G2 phase. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.