Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Calreticulin Antikörper

Der Maus Monoklonal Anti-Calreticulin-Antikörper wurde für WB, IHC, ELISA und ICC validiert. Er ist geeignet, Calreticulin in Proben von Human und Maus zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN1724687

Kurzübersicht für Calreticulin Antikörper (ABIN1724687)

Target

Alle Calreticulin (CALR) Antikörper anzeigen
Calreticulin (CALR)

Reaktivität

  • 138
  • 71
  • 68
  • 9
  • 9
  • 6
  • 6
  • 6
  • 5
  • 5
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 137
  • 25
  • 2
  • 1
Maus

Klonalität

  • 126
  • 39
Monoklonal

Konjugat

  • 97
  • 13
  • 12
  • 7
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Calreticulin Antikörper ist unkonjugiert

Applikation

  • 134
  • 86
  • 56
  • 49
  • 46
  • 43
  • 35
  • 15
  • 14
  • 13
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Klon

1G6A7
  • Verwendungszweck

    Calreticulin Antibody

    Sequenz

    EEEDVPGQAK DELC

    Aufreinigung

    Ascitic fluid

    Immunogen

    Synthetic peptide corresponding to aa (EEEDVPGQAKDELC) of human Calreticulin, conjugated to KLH.

    Isotyp

    IgG2a
  • Applikationshinweise

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Tan, Chen, Li, Mabuchi, Bouvier: "The calcium- and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain." in: Biochimica et biophysica acta, Vol. 1760, Issue 5, pp. 745-53, (2006) (PubMed).

  • Target

    Calreticulin (CALR)

    Andere Bezeichnung

    Calreticulin

    Hintergrund

    Calreticulin, also known as RO, CRT, SSA, cC1qR, FLJ26680, CALR. Entrez Protein NP_004334. It is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

    Molekulargewicht

    48 kDa

    Gen-ID

    811

    NCBI Accession

    NP_004334

    UniProt

    P27797

    Pathways

    Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
Sie sind hier:
Chat with us!