MSH2 Antikörper

Produktnummer ABIN1724643

Dieses Anti-MSH2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MSH2 in WB, ELISA, IHC und ICC. Geeignet für Human und Affe.

Kurzübersicht für MSH2 Antikörper (ABIN1724643)

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MSH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: 1B3A8A8

Produktdetails anti-MSH2 Antikörper

Verwendungszweck: MSH2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human MSH2 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Andere Bezeichnung: MSH2

Hintergrund: MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA
replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic
colorectal carcinoma. MSHS mutations are responsible for 50 % of inherited non-polyposis colorectal
(HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic
information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI).
These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.

Molekulargewicht: 105 kDa

Gen-ID: 4436

UniProt: P43246

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response