CTLA4 Antikörper (AA 75-170)

Produktnummer ABIN1714514

Der Kaninchen Polyklonal Anti-CTLA4-Antikörper wurde für FACS, WB, ELISA, IHC (p) und IF (p) validiert. Er ist geeignet, CTLA4 in Proben von Human, Maus und Ratte zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für CTLA4 Antikörper (AA 75-170) (ABIN1714514)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-CTLA4 Antikörper

Bindungsspezifität: AA 75-170

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTLA-4/CD152

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CTLA4 Antikörper (ABIN1714514)

Schlößer, Drebber, Kloth, Thelen, Rothschild, Haase, Garcia-Marquez, Wennhold, Berlth, Urbanski, Alakus, Schauss, Shimabukuro-Vornhagen, Theurich, Warnecke-Ebertz, Stippel, Zippelius, Büttner, Hallek et al.: "Immune checkpoints programmed death 1 ligand 1 and cytotoxic T lymphocyte associated molecule 4 in gastric adenocarcinoma. ..." in: Oncoimmunology, Vol. 5, Issue 5, pp. e1100789, (2016) (PubMed).

Tamaka, Seike, Hagiwara, Sato, Ohtsu: "Histamine suppresses regulatory T cells mediated by TGF-? in murine chronic allergic contact dermatitis." in: Experimental dermatology, Vol. 24, Issue 4, pp. 280-4, (2015) (PubMed).

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: CTLA4

Hintergrund:

Synonyms: CD, GSE, GRD4, CD152, CTLA-4, IDDM12, CELIAC3, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA4

Background: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Gen-ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints