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Nemo-Like Kinase Antikörper (pThr298)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Nemo-Like Kinase in WB, ELISA, IF (cc), IF (p), IHC (p), ICC und IHC (fro). Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN1714333

Kurzübersicht für Nemo-Like Kinase Antikörper (pThr298) (ABIN1714333)

Target

Alle Nemo-Like Kinase (NLK) Antikörper anzeigen
Nemo-Like Kinase (NLK)

Reaktivität

  • 73
  • 34
  • 12
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 74
  • 4
Kaninchen

Klonalität

  • 73
  • 5
Polyklonal

Konjugat

  • 28
  • 6
  • 5
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Nemo-Like Kinase Antikörper ist unkonjugiert

Applikation

  • 70
  • 30
  • 25
  • 25
  • 19
  • 12
  • 10
  • 10
  • 9
  • 5
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 15
    • 14
    • 8
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr298

    Kreuzreaktivität

    Human, Maus

    Homologie

    Rat,Cow,Sheep,Pig,Chicken,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human Nemo-like kinase around the phosphorylation site of Thr298

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Nemo-Like Kinase (NLK)

    Andere Bezeichnung

    Nemo-like kinase

    Hintergrund

    Synonyms: Nemo-like kinase Thr298, Nemo-like kinase T298, p-Nemo-like kinase Thr298, p-Nemo-like kinase T298, DKFZp761G1211, FLJ21033, LAK1, Nemo like kinase, Nemo-like kinase, Nlk, NLK_HUMAN, Protein LAK1, Serine/threonine protein kinase NLK, Serine/threonine-protein kinase NLK.

    Background: Nemo-like kinase (NLK) plays a role in cell fate determination and is required for differentiation of bone marrow stromal cells. It acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. It may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. (referenced from swissprot)

    Pathways

    Ubiquitin Proteasome Pathway
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