FFAR1 Antikörper (PE-Cy7)

Produktnummer ABIN1713292

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FFAR1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund und Schwein.

Kurzübersicht für FFAR1 Antikörper (PE-Cy7) (ABIN1713292)

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Reaktivität: Human, Maus, Ratte, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FFAR1 Antikörper ist konjugiert mit PE-Cy7

Applikation: Western Blotting (WB)

Produktdetails anti-FFAR1 Antikörper (PE-Cy7)

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPR40

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FFAR1

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Andere Bezeichnung: GPR40

Hintergrund:

Synonyms: FFA1R, GPR40, GPCR40, Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1

Background: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis, receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Gen-ID: 2864

UniProt: O14842

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Carbohydrate Homeostasis