GPBAR1 Antikörper (PE-Cy5.5)

Produktnummer ABIN1713077

Der Kaninchen Polyklonal Anti-GPBAR1-Antikörper wurde für WB validiert. Er ist geeignet, GPBAR1 in Proben von Human zu detektieren.

Kurzübersicht für GPBAR1 Antikörper (PE-Cy5.5) (ABIN1713077)

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPBAR1 Antikörper ist konjugiert mit PE-Cy5.5

Applikation: Western Blotting (WB)

Produktdetails anti-GPBAR1 Antikörper (PE-Cy5.5)

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPBAR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GPBAR1

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Andere Bezeichnung: GPCR TGR5/GPBAR1

Hintergrund:

Synonyms: BG 37, BG37, G protein coupled bile acid receptor 1, G protein coupled bile acid receptor BG 37, G protein coupled bile acid receptor BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPBAR1, GPCR 19, GPCR, GPCR19, GPR 131, GPR131, hBG 37, hBG37, hGPCR 19, hGPCR19, M BAR, M-BAR, Membrane bile acid receptor, Membrane type receptor for bile acids, Membrane-type receptor for bile acids, MGC40597, TGR 5, TGR5.

Background: The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

Gen-ID: 151306

Pathways: WNT Signalweg, Hormone Transport, Sensory Perception of Sound