ERBB4 Antikörper (pTyr1056) (HRP)

Produktnummer ABIN1712584

Produktdetails anti-ERBB4 Antikörper (HRP)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Bindungsspezifität: pTyr1056

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERBB4 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HER4 around the phosphorylation site of Tyr1056 [PA(p-Y)TP]

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Andere Bezeichnung: HER4 (ERBB4 Produkte)

Synonyme: erbb4 antikoerper, si:ch211-227n20.1 antikoerper, Her4 antikoerper, c-erbB-4 antikoerper, HER4 antikoerper, p180erbB4 antikoerper, erb-b2 receptor tyrosine kinase 4 antikoerper, erb-b2 receptor tyrosine kinase 4a antikoerper, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antikoerper, erb-b2 receptor tyrosine kinase 4 L homeolog antikoerper, receptor tyrosine-protein kinase ErbB-4 antikoerper, ERBB4 antikoerper, erbb4a antikoerper, erbb4 antikoerper, erbb4.L antikoerper, Tsp_13582 antikoerper, Erbb4 antikoerper

Hintergrund:

Synonyms: ErbB 4 phospho Y1056, p-ErbB 4 phospho Y1056, ErbB4, HER 4, HER4, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, MGC138404, P180erbB4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4,Tyrosine kinase type cell surface receptor HER4, v erb a avian erythroblastic leukemia viral oncogene homolog like 4, v erb a erythroblastic leukemia viral oncogene homolog 4, Verba avian erythroblastic leukemia viral oncogene homolog like 4, Verba erythroblastic leukemia viral oncogene homolog 4, VERBB2.

Background: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

Gen-ID: 2066

UniProt: Q15303

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung