GPR17 Antikörper (AA 2-100) (HRP)

Produktnummer ABIN1711310

Der Kaninchen Polyklonal Anti-GPR17-Antikörper wurde für WB, ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, GPR17 in Proben von Human zu detektieren.

Kurzübersicht für GPR17 Antikörper (AA 2-100) (HRP) (ABIN1711310)

Target: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR17 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GPR17 Antikörper (HRP)

Bindungsspezifität: AA 2-100

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human G protein coupled receptor 17

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GPR17

Target: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Andere Bezeichnung: GPR17

Hintergrund:

Synonyms: DKFZp686M18273, G protein coupled receptor 17, G-protein coupled receptor 17, GPR 17, Gpr17, GPR17_HUMAN, P2Y like receptor, P2Y-like receptor, Probable P2Y purinoceptor GPR 17, Probable P2Y purinoceptor GPR17, R12, UDP/CysLT receptor, Uracil nucleotide/cysteinyl leukotriene receptor, GPCR GPR17.

Background: G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.

Gen-ID: 2840

UniProt: Q13304