GPR17 Antikörper (Intracellular, Loop 3)

Produktnummer ABIN7886434

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GPR17 in WB, IF und IHC. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für GPR17 Antikörper (Intracellular, Loop 3) (ABIN7886434)

Target: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-GPR17 Antikörper

Bindungsspezifität: AA 220-232, Intracellular, Loop 3

Verwendungszweck: A Rabbit Polyclonal Antibody to GPR17 Receptor

Kreuzreaktivität: Maus, Ratte

Kreuzreaktivität (Details): Not recommended for human samples.

Homologie: Mouse - identical

Produktmerkmale: Anti-GPR17 Antibody (ABIN7043149, ABIN7044435 and ABIN7044436) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GPR17 from rat and mouse samples. It is unlikely to recognize the protein from human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RQGPRIEKHLKNK, corresponding to amino acid residues 220-232 of rat GPR17

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235376)

Blocking Peptide: (ABIN7235376)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu GPR17

Target: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Andere Bezeichnung: GPR17

Hintergrund:

Synonyms: G-protein coupled receptor 17, Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT Receptor, P2Y-like receptor

Description: GPR17 is an orphan receptor that can be double-activated by uracil and cysteinyl-leukotriene (CysLT). It is phylogenetically related to both purinergic P2Y and CysLT receptors. GPR17 belongs to the superfamily of G-protein coupled receptors (GPCRs)4.GPR17 expression is highly detected in the brain, kidney, and heart. In the brain, GPR17 is mainly distributed in white matter, gray matter, subependymal zone, and corpus callosum1.Studies have shown that GPR17 receptor plays an important role in spinal cord injury, myelin sheath injury, cerebral ischemic injury, where its expression is extremely upregulated1,2.GPR17 activation promotes oligodendrocyte differentiation and progression toward mature myelin-forming cells. Thus, GPR17 modulators may be used as therapeutic tools to treat pathologies associated with myelin repair in CNS demyelinating diseases3.

Gen-ID: 767613

NCBI Accession: NM_001161415

UniProt: Q09QM4