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APLF Antikörper (AA 421-511) (HRP)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch APLF in ELISA, WB, IHC (fro) und IHC (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN1711216

Kurzübersicht für APLF Antikörper (AA 421-511) (HRP) (ABIN1711216)

Target

Alle APLF Antikörper anzeigen
APLF (Aprataxin and PNKP Like Factor (APLF))

Reaktivität

  • 32
  • 8
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 32
Kaninchen

Klonalität

  • 32
Polyklonal

Konjugat

  • 13
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser APLF Antikörper ist konjugiert mit HRP

Applikation

  • 24
  • 13
  • 13
  • 11
  • 8
  • 3
  • 2
  • 1
ELISA, Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 14
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 421-511

    Homologie

    Human,Mouse,Rat

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human APLF

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handhabung

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    APLF (Aprataxin and PNKP Like Factor (APLF))

    Andere Bezeichnung

    APLF

    Hintergrund

    Synonyms: 2010301N04Rik, AI452191, Aplf, APLF_HUMAN, Aprataxin and pnk-like factor, Apurinic-apyrimidinic endonuclease APLF, C2orf13, PNK and APTX like FHA protein, PNK and APTX-like FHA domain-containing protein, RGD1565557, XIP1, XRCC1 interacting protein 1, XRCC1-interacting protein 1.

    Background: APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8 % of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.

    Gen-ID

    200558

    Pathways

    DNA Reparatur
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