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TYROBP Antikörper (AA 11-100) (HRP)

Der Kaninchen Polyklonal Anti-TYROBP-Antikörper wurde für ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, TYROBP in Proben von Human zu detektieren.
Produktnummer ABIN1710995

Kurzübersicht für TYROBP Antikörper (AA 11-100) (HRP) (ABIN1710995)

Target

Alle TYROBP Antikörper anzeigen
TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reaktivität

  • 54
  • 19
  • 3
Human

Wirt

  • 69
  • 2
  • 1
Kaninchen

Klonalität

  • 61
  • 11
Polyklonal

Konjugat

  • 22
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser TYROBP Antikörper ist konjugiert mit HRP

Applikation

  • 42
  • 31
  • 26
  • 26
  • 17
  • 17
  • 11
  • 5
  • 5
  • 4
  • 1
  • 1
  • 1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 16
    • 14
    • 13
    • 9
    • 1
    • 1
    • 1
    • 1
    AA 11-100

    Homologie

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human DAP12

    Isotyp

    IgG
  • Applikationshinweise

    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handhabung

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

    Andere Bezeichnung

    DAP12

    Hintergrund

    Synonyms: DAP 12, DAP12, DNAX activation protein 12, DNAX-activation protein 12, KAR-associated protein, KARAP, Killer activating receptor associated protein, Killer-activating receptor-associated protein, PLOSL, TYOBP_HUMAN, TYRO protein tyrosine kinase binding protein, TYRO protein tyrosine kinase-binding protein, TYROBP.

    Background: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

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