ERBB4 Antikörper (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian)) (pTyr1258) (Cy5)

Details for Product anti-ERBB4 Antibody No. ABIN1705048
Antigen
  • erbb4
  • si:ch211-227n20.1
  • Her4
  • c-erbB-4
  • HER4
  • p180erbB4
  • erb-b2 receptor tyrosine kinase 4
  • erb-b2 receptor tyrosine kinase 4a
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
  • erb-b2 receptor tyrosine kinase 4 L homeolog
  • receptor tyrosine-protein kinase ErbB-4
  • ERBB4
  • erbb4a
  • erbb4
  • erbb4.L
  • Tsp_13582
  • Erbb4
Epitop
pTyr1258
43
36
35
34
17
17
17
15
12
11
11
10
7
6
5
4
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
377
192
177
8
6
4
4
4
4
3
2
2
2
1
1
Wirt
Kaninchen
341
45
Klonalität
Polyklonal
Konjugat
Dieser ERBB4 Antikörper ist konjugiert mit Cy5
23
18
16
13
13
10
10
10
10
10
10
9
5
5
5
5
5
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
200
140
128
66
64
27
21
16
12
9
3
2
1
1
1
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human HER4 around the phosphorylation site of Tyr1258 [PD(p-Y)LQ ]
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere ERBB4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Her4 (ERBB4 Antibody Abstract)
Hintergrund

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

Synonyms: ErbB 4 phospho Y1258, p-ErbB 4 phospho Y1258, ErbB4, HER 4, HER4, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, MGC138404, P180erbB4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4,Tyrosine kinase type cell surface receptor HER4, v erb a avian erythroblastic leukemia viral oncogene homolog like 4, v erb a erythroblastic leukemia viral oncogene homolog 4, Verba avian erythroblastic leukemia viral oncogene homolog like 4, Verba erythroblastic leukemia viral oncogene homolog 4, VERBB2.

Gen-ID 2066
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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